Most professional basketball players notice a physical decline in their mid-30s, but sports analysts argue that Lebron James is still playing like he’s in his late-20s. The idea is that not everyone accumulates damage to their cells and tissues at the same rate.įor example, Lebron James, a four-time NBA champion, is a 36-year old athlete. Your biological age determines how old you are by the state of your physical condition. Your biological age is a better indicator of your physical condition. It’s the number of candles on your birthday cake.īut what if you are counting wrong? What if your chronological age is not the best indicator of your real age?
I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.Your chronological age is the number of years, months, and days since you were born.
I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as. I confirm that all necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived, and that any patient/participant/sample identifiers included were not known to anyone (e.g., hospital staff, patients or participants themselves) outside the research group so cannot be used to identify individuals. The Ethics Committee of the Charite University hospital approved the BASE-II study (approval number EA2/029/09). The Ethics Commission of the Berlin Chamber of Physicians (Aerztekammer Berlin) approved the BASE study prior to the first assessments in 1990 (approvals were not numbered at that time). The details of the IRB/oversight body that provided approval or exemption for the research described are given below: I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained. This work was supported by a grant of the Deutsche Forschungsgemeinschaft (grant number DE 842/7-1). Additional contributions (e.g., equipment, logistics, personnel) are made from each of the other participating sites. Another source of funding is the Max Planck Institute for Human Development, Berlin, Germany. This work also reports data from the BASE-II project, which was supported by the German Federal Ministry of Education and Research (Bundesministerium fuer Bildung und Forschung, BMBF) under grant numbers #01UW0808 #16SV5536K, #16SV5537, #16SV5538, #16SV5837 #01GL1716A and #01GL1716B.
Funding Statementįinancial support for the Berlin Aging Study came from the Max Planck Society the Free University of Berlin the German Federal Ministry for Research and Technology (1989-1991, 13 TA 011 & 13 TA 011/A) the German Federal Ministry for Family, Senior Citizens, Women, and Youth (1992-1998, 314-1722-102/9 & 314-1722-102/9a) and the Berlin-Brandenburg Academy of Sciences‟ Research Group on Aging and Societal Development (1994-1999). The authors have declared no competing interest. We discuss the importance of biological age as one indicator of aging.
Similarly, in BASE-II, biological age was associated with physician-observed morbidity and subjective health, over and above the effects of chronological age, sex, and education as well as alternative biomarkers including telomere length, DNA methylation age, skin age, and subjective age. In BASE, older biological age was associated with more physician-observed morbidity and higher mortality hazards, over and above the effects of chronological age, sex, and education. We calculated biological age using those 12 parameters that individually predicted mortality hazards over 26 years in BASE. Instead, in the current study, we identified parameters based on standard laboratory blood tests across metabolic, cardiovascular, inflammatory, and kidney functioning that had been assessed in the Berlin Aging Study (BASE n = 384) and Berlin Aging Study II (BASE-II, n = 1,517). Biomarkers defining biological age are typically laborious or expensive to assess.